Two lupane and four ursane triterpenes, namely epilupeol ( 1 ), lupeol acetate ( 2 ), ursolic acid ( 3 ), brein ( 4 ), 3β 11α-dihydroxy urs-12-ene ( 5 ) and ursolic acid lactone ( 6 ) were isolated from aerial parts of Kleinia odora and identified. Compounds 1 and 3 – 6 were isolated for the first time from K. odora. The triterpene constituents were investigated for antiprotozoal potential against erythrocytic schizonts of Plasmodium falciparum , intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei . Cytotoxicity was determined against MRC-5 fibroblasts to assess selectivity. The ursane triterpenes were found to be active against more than one type of the tested parasites, with the exception of compound 6 . This is also the first report on the occurrence of ursane type triterpenes in the genus Kleinia and their antiprotozoal potential against P. falciparum , L. infantum , T. cruzi , and T. brucei .
【저자키워드】 triterpenes, Antileishmanial, antiplasmodial, Kleinia odora, antitrypanosomal,