Abstract
Objectives
To assess whether COVID-19 could be a concurrent factor in the genesis and/or worsening of stroke and to provide data on COVID-19 –associated stroke patients during the first pandemic wave and comparative data on COVID-19 negative stroke patients in the same period.
Materials and Methods
This is a retrospective, observational, case-control, single centre study, carried out in a General Hospital in northern Italy. Sixty-three consecutive stroke patients were included, COVID-19-associated stroke was classified as cases and non COVID-19-associated stroke as controls.
Results
A total of 19/63 (28.8%) had a COVID-19-associated stroke, 11 /63 (17.5%) were haemorrhagic and 52/63 (82.5%) ischaemic. COVID-19-associated strokes were more severe (p-value 0.019) and had a higher risk of severe disability and/or death (OR 3.79, CI 95%: 1.21-11.93, p-value 0.19). The COVID-19-associated stroke patients with onset during hospitalization for COVID-19 had a more severe stroke than patients with COVID-19 onset during hospitalization for stroke (p-value 0.019).
Conclusion
Although no relationship was observed between the stroke aetiology and COVID-19, intriguingly, COVID-associated stroke turned out to be more severe and disabling. Hopefully, further studies will provide more data and help in the management of this emerging population.
【저자키워드】 COVID-19, SARS-CoV-2, case-control study, Large vessel occlusion, COVID-19-associated stroke, 【초록키워드】 pandemic, Hospitalization, stroke, Italy, management, Patient, death, Case-control, retrospective, higher risk, worsening, help, material, aetiology, objective, controls, Result, carried, COVID-19 negative, Hopefully, patients with COVID-19,