Abstract
Background
Since the start of COVID-19 vaccination worldwide, there have been several reports of inflammatory demyelinating diseases of the central nervous system (CNS-IDDs) following vaccination.
Methods
We prospectively collected cases of new-onset CNS-IDDs with a temporal relationship between disease onset and COVID-19 vaccination and investigated their proportion among newly registered cases of CNS-IDD over the past year.
Results
Among 117 cases, 10 (8.5%) had their first disease manifestation within one month following COVID-19 vaccination: 2 multiple sclerosis, 2 neuromyelitis optica spectrum disorder, 3 MOG antibody-associated disease, and 3 unclassified CNS-IDDs.
Conclusion
This observation suggests that COVID-19 vaccination may trigger the onset of various CNS-IDDs in susceptible individuals.
【저자키워드】 multiple sclerosis, COVID-19 vaccination, MOG antibody-associated disease, Neuromyelitis optica spectrum disorder, Demyelinating disease, 【초록키워드】 COVID-19, vaccination, Central nervous system, disease, MOG, Inflammatory, disease onset, observation, Registered, susceptible individuals, disease manifestation, disorder, Result, collected, proportion, investigated, 【제목키워드】 Onset, CNS, Inflammatory, demyelination disease,