Background: Endemic Burkitt’s lymphoma (eBL) has been associated with Epstein–Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. But recent evidence suggests that other risk factors are involved. Methods: We hypothesised that selenoprotein glutathione peroxidase (GPx), a surrogate of nutritional status, is an important biomarker for eBL risk. We measured plasma GPx, anthropometric markers of malnutrition, EBV viral loads and malaria parasitaemia in children aged 1–9 years ( n =258) from two locations in Nyanza Province, Kenya, with higher-than-expected and lower-than-expected incidence of eBL. The study participants were malaria asymptomatic children from the community. Results: Children from eBL high-incidence areas had significantly lower GPx levels, high EBV viral load and more evidence of chronic malnutrition than children from eBL low-incidence areas (all P <0.001). Additionally, GPx levels were significantly lower in children with the highest EBV viral load and for those with P. falciparum infections ( P =0.035 and P =0.004, respectively). Conclusions: These results suggest that selenium deficiency may be a risk factor for eBL.
【저자키워드】 malaria, Malnutrition, pediatric cancer, selenium deficiency, Epstein–Barr virus (EBV), endemic Burkitt's lymphoma,