Abstract
Severe coronavirus (COVID-19) infection has been reportedly associated with a high risk of thromboembolism. Developing macrovascular thrombotic complications, including myocardial injury/infarction, venous thromboembolism, and stroke have been observed in one-third of severe COVID-19 hospitalized patients, leading to an increase in mortality and morbidity. The diagnosis of COVID-19 associated coagulopathy may be challenging because there are close similarities between pulmonary embolism and severe COVID-19 disease. Therefore, a critical step in improving the clinical outcome of patients with hospitalized COVID-19 is the recognition of coagulation abnormalities and the identification of patients with poor prognoses, prophylactic guidance, or antithrombotic therapy. Prescribing anticoagulants in all patients hospitalized with COVID-19 and 2–6 weeks post-hospital discharge in the absence of contraindications is recommended by most consensus documents published on behalf of professional societies. However, a decision on some variable factors such as intensity and duration of anticoagulation may be made based on an individual case and needs future randomized trial studies. Regarding little information on this subject, this study aims to review how inflammation and thrombosis are related to COVID-19 patients, discuss the types of thrombosis in these patients, and summarize the diagnosis and treatment of thrombosis in COVID19 patients.
【저자키워드】 COVID-19, Inflammation, anticoagulation, thrombosis, 【초록키워드】 Treatment, coronavirus, Mortality, severe COVID-19, Thrombotic complications, stroke, randomized trial, Infection, Diagnosis, Prophylactic, hospitalized patients, Venous Thromboembolism, discharge, Coagulation, Coagulopathy, Clinical outcome, morbidity, Patient, Thromboembolism, information, Critical, patients, Guidance, severe COVID-19 disease, COVID-19 patients, antithrombotic therapy, Anticoagulant, similarity, high risk, intensity, Consensus, Factor, subject, contraindication, prescribing, abnormality, COVID19 patients, hospitalized COVID-19, Myocardial, absence, Developing, increase in, diagnosis of COVID-19, patients hospitalized, with COVID-19, 【제목키워드】 Treatment, Infection, Diagnosis, risk, pathophysiological mechanism, with COVID-19,