Abstract
Introduction and importance
Although some immunocompetent patients have developed invasive aspergillosis, the vast majority of cases are seen in immunocompromised patients. COVID-19 infection has been proposed to cause immune dysfunction or suppression, which predisposes patients to fungal co-infections such as mucormycosis and aspergillosis.
Case presentation
A 58-year-old woman was admitted to the hospital with confusion, dysarthria, and loss of consciousness. The patient had a 1-month prior history of severe COVID-19 infection. A computerized tomography (CT) scan and a magnetic resonance imaging (MRI) revealed an intraventricular lesion with perilesional edema and a significant midline shift, which was initially thought to be an intraventricular tumor. Following a posterior parietal craniotomy, the lesion was resected via a transcortical approach from the posterior parietal region to the right lateral ventricle. Histopathological findings confirmed intraventricular aspergillosis (IVA). The patient was treated with intravenous amphotericin B for two months and discharged with oral variconazole for 4 months.
Discussion
Covid-19 infections can result in- dissemination of fungal diseases such as aspergillosis. As a minor component of cerebral aspergillosis with a poor prognosis, intraventricular aspergillosis necessitates prompt treatment, which includes surgical resection and the administration of anti-fungal medications.
Conclusion
Infection with COVID-19 causes immune dysfunction, which leads to fungal co-infection, including CNS aspergillosis. As a result, all COVID-19 patients who present with acute neurologic symptoms should have CNS aspergillosis considered in their differential diagnosis.
【저자키워드】 COVID-19, SARS-CoV-2, Case report, aspergillosis, CNS, Intraventricular space, 【초록키워드】 Treatment, magnetic resonance imaging, hospital, Infection, Immunocompromised patients, Symptom, medications, MRI, Computerized tomography, COVID-19 infection, Mucormycosis, Patient, edema, Co-infection, dissemination, differential diagnosis, fungal, administration, immune dysfunction, COVID-19 patient, intravenous, fungal disease, Confusion, Severe COVID-19 Infection, Loss of consciousness, poor prognosis, surgical resection, neurologic, approach, invasive, thought, include, treated, majority, cause, discharged, intraventricular, transcortical, with COVID-19, 【제목키워드】 Patient,