Abstract
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global epidemic and poses a major threat to public health. In addition to COVID-19 manifesting as a respiratory disease, patients with severe disease also have complications in extrapulmonary organs, including liver damage. Abnormal liver function is relatively common in COVID-19 patients; its clinical manifestations can range from an asymptomatic elevation of liver enzymes to decompensated hepatic function, and liver injury is more prevalent in severe and critical patients. Liver injury in COVID-19 patients is a comprehensive effect mediated by multiple factors, including liver damage directly caused by SARS-CoV-2, drug-induced liver damage, hypoxia reperfusion dysfunction, immune stress and inflammatory factor storms. Patients with chronic liver disease (especially alcohol-related liver disease, nonalcoholic fatty liver disease, cirrhosis and hepatocellular carcinoma) are at increased risk of severe disease and death after infection with SARS-CoV-2, and COVID-19 aggravates liver damage in patients with chronic liver disease. This article reviews the latest SARS-CoV-2 reports, focusing on the liver damage caused by COVID-19 and the underlying mechanism, and expounds on the risk, treatment and vaccine safety of SARS-CoV-2 in patients with chronic liver disease and liver transplantation.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, Liver injury, liver transplant, chronic liver disease, 【초록키워드】 Treatment, public health, Coronavirus disease 2019, Stress, hypoxia, risk, immune, Epidemic, Asymptomatic, cirrhosis, Respiratory disease, Patient, Liver transplantation, Factors, death, Liver function, Complication, disease, Critical, patients, mechanism, Coronavirus-2, Liver damage, Injury, severe disease, Liver disease, COVID-19 patient, Hepatocellular carcinoma, liver enzyme, clinical manifestation, dysfunction, reperfusion, acute respiratory syndrome, increased risk, extrapulmonary organs, prevalent, caused, addition, aggravate, hepatic function, infection with SARS-CoV-2, inflammatory factor storms, nonalcoholic fatty liver, 【제목키워드】 Treatment, Characteristics, clinical, management, liver, pathophysiological mechanism,