Abstract
Introduction
To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam.
Methods
This retrospective cohort study was performed at Children’s Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included.
Results
Of the 850 cases admitting to COVID-19 department, 555 children with COVID-19 confirmed by positive RT-PCR and treated at our center for more than 72 h. Median age of confirmed cases was 22.3 (IQR: 3.2–88.6) months, 55.1% were male, and 84.5% had a history of close contact with confirmed COVID-19 patients. The rate of mild, moderate and severe/critical cases was 73,7%, 9.0% and 17.3%, respectively. One hundred ninety-two children (34.6%) had underlying diseases, in which, neurologic disease was the most common underlying disease (7.9%). Underlying disease, dyspnea, elevated CRP >20 mg/L and elevated ferritin were independent factors related to severe illness. Twenty-point two percent of patients in our study needed respiratory support, including 22 invasive mechanical ventilation cases. Eighteen cases (3.2%) died because of severe comorbidities, poor response to treatment.
Conclusions
In our study, the severe/critical and mortality rates in pediatric COVID-19 cases were relatively high. All fatal cases had severe comorbidities. Underlying disease, dyspnea, and elevated inflammatory markers were independent factors related to severity in pediatric COVID-19 cases.
【저자키워드】 COVID-19, SARS-CoV-2, Risk factors, pediatrics, 【초록키워드】 Treatment, Mortality, pediatric, children, severity, disease severity, Comorbidities, CRP, ferritin, underlying disease, risk factor, RT-PCR, Dyspnea, male, Patient, Mild, age, Inflammatory marker, mortality rate, underlying diseases, disease, moderate, COVID-19 patients, positive RT-PCR, Invasive mechanical ventilation, close contact, Respiratory Support, COVID-19 cases, confirmed case, retrospective cohort study, Factor, COVID-19 case, positive, neurologic, independent, Result, died, elevated, was performed, treated, children with COVID-19, 【제목키워드】 Mortality, children, disease severity, hospital, Factor,