Abstract
Purpose
Cancer patients with COVID-19 likely express biomarker changes in circulation. However, the biomarkers used in SARS-CoV-2 infected cancer patients for COVID-19 severity and prognosis are largely unclear. Therefore, this systematic review aims to determine what biomarkers were measured in cancer patients with COVID-19 and their prognostic utility.
Methods
A systematic literature review in PubMed, Embase, and Scopus was performed on June 16th, 2021. The search keywords coronavirus, neoplasm, biomarkers, and disease progression were used to filter out 17 eligible studies, which were then carefully evaluated.
Results
A total of 4,168 patients, 16 types of cancer, and 60 biomarkers were included. Seven up-regulated markers, including CRP, d-dimer, ferritin, IL-2R, IL-6, LDH, and PCT, were identified in eligible studies. Albumin and hemoglobin were significantly down-regulated in cancer patients with COVID-19. Moreover, we observed that the SARS-CoV-2 infected cancer patients with lower CRP, ferritin, and LDH levels successfully survived from COVID-19 treatments.
Conclusion
Several important clinical biomarkers, such as CRP, ferritin, and LDH, may serve as the prognostic markers to predict the outcomes following COVID-19 treatment and monitor the deterioration of COVID-19 in cancer patients.
【저자키워드】 COVID-19, Prognostic biomarkers, SARS-CoV-2, Immunotherapy, Cancer, 【초록키워드】 Treatment, coronavirus, Biomarker, Biomarkers, Prognosis, IL-6, COVID-19 severity, LDH, systematic review, CRP, ferritin, outcome, COVID-19 treatments, Disease progression, Deterioration, Cancer patients, Prognostic marker, hemoglobin, circulation, prognostic, utility, patients, predict, neoplasm, cancer patient, literature review, Express, MONITOR, PCT, Result, significantly, evaluated, was performed, were used, determine, changes in, up-regulated, survived, were measured, down-regulated, eligible, patients with COVID-19, the SARS-CoV-2, with COVID-19, 【제목키워드】 systematic review, cancer patient, serum biomarker,