Abstract
COVID-19 was discovered in China for the first time in December 2019 and was declared a pandemic by the World Health Organization on March 11, 2020. Due to its rapid geographic expansion over the last three years, it has now become a global health issue. The infection is caused by SARS-CoV-2, which is obtained from a zoonotic source and transmitted directly or through contact. Following exposure, the immune system becomes hyperactive resulting in the production of pro-inflammatory cytokines, particularly interleukin-6 (IL-6), a naturally occurring pleiotropic cytokine that plays a significant role in respiratory failure and multi-organ dysfunction. This massive inflammatory phenomenon is reminiscent of cytokine release syndrome (CRS) or “cytokine storm”, which may be at the root of many severe complications. In fact, serum IL-6 levels are significantly high in patients with severe Covid-19 disease. The goal of treatment is to change the cytokine’s concentration or activity. Interleukin-6 production could be inhibited, reducing inflammation and so serving as a therapeutic target. anti-interleukin-6 receptor monoclonal antibodies have been proven to reduce the severity of COVID-19 in clinical trials aimed at clarifying the function of immunoregulation. As a result, the Il-6 assay is a reliable predictor of morbidity and mortality at the time of infection diagnosis. The aim of our study is to highlight the role of interleukin 6 as biomarker of the COVID- 19 progression.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, Biomarker, interleukin-6, monoclonal antibodies, 【초록키워드】 Treatment, Inflammation, clinical trial, pandemic, Respiratory failure, multi-organ dysfunction, IL-6, monoclonal antibody, Infection, Diagnosis, cytokine, progression, immune system, Cytokine release syndrome, COVID, China, serum, Health, severity of COVID-19, zoonotic, Patient, pro-inflammatory cytokines, morbidity and mortality, receptor, disease, immunoregulation, CRS, Concentration, therapeutic target, World Health Organization, severe complications, highlight, resulting, caused, significantly, transmitted, inhibited, reducing, reduce, pleiotropic, “cytokine storm”, IL-6 level, massive inflammatory, through contact, 【제목키워드】 interleukin, COVID-19 progression,