The immune response after SARS-CoV-2 vaccine administration appears to be characterized by high inter-individual variation, even in SARS-CoV-2 positive subjects, who could have experienced different post-infection, unresolved conditions. We monitored anti-SARS-CoV-2 IgG levels and kinetics along with circulating biomarkers in a cohort of 175 healthcare workers during early immunization with COVID-19 mRNA-LNP BNT162b2 vaccine, to identify the associated factors. Subjects with a previous SARS-CoV-2 infection were characterized by higher BMI and CRP levels and lower neutrophil count with respect to naïve subjects. Baseline IgG levels resulted associated with CRP independently on BMI and inflammatory diseases. Among 137 subjects undergoing vaccination and monitored after the first and the second dose, three kinetic patterns were identified. The pattern showing a rapid growth was characterized by higher IgG levels at baseline and higher CRP and MCHC levels than negative subjects. Subjects previously exposed to SARS-CoV-2 showed higher levels of CRP, suggesting persistence of unresolved inflammation. These levels are the main determinant of IgG levels at baseline and characterized subjects belonging to the best performing, post-vaccine antibody kinetic pattern.
【저자키워드】 viral infection, Risk factors, Epidemiology, RNA vaccines, Predictive markers, 【초록키워드】 Inflammatory diseases, SARS-CoV-2, Inflammation, BNT162b2 vaccine, immune response, vaccination, Biomarker, antibody, SARS-COV-2 infection, neutrophil, CRP, immunization, healthcare worker, SARS-CoV-2 vaccine, BNT162b2, Kinetics, Cohort, anti-SARS-CoV-2 IgG, persistence, Factors, BMI, pattern, administration, kinetic, best, Post-infection, subject, second dose, growth, naïve subjects, CRP levels, IgG levels, neutrophil count, circulating, CRP level, positive, MCHC, Inter-individual variation, Post-vaccine, identify, characterized, appear, subjects, conditions, baseline, IgG level, with COVID-19, 【제목키워드】 Inflammation, Vaccine, antibody,