Summary
The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical in preventing widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings. We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex. It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser-engraved graphene electrodes. We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges. We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19-positive and COVID-19-negative blood and saliva samples. Based on this pilot study, our multiplexed immunosensor platform may allow for high-frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring.
【저자키워드】 MAP6: Development, 【초록키워드】 COVID-19, antibodies, SARS-CoV-2, Saliva, COVID-19 pandemic, Infection, C-reactive protein, nucleocapsid protein, Asymptomatic individuals, COVID-19 infection, Community, presymptomatic, Critical, platform, Blood, Inflammatory biomarker, IgM and IgG, Viral antigen, pilot study, selective, applicability, public health systems, widespread, detect, evaluated, diagnosis and monitoring, the SARS-CoV-2, 【제목키워드】 COVID-19, SARS-CoV-2, Telemedicine, Rapid, monitoring,