Abstract
Platelets are at the crossroads between thrombosis and inflammation. When activated, platelets can shed bioactive extracellular vesicles [pEVs] that share the hemostatic potential of their parent cells and act as bioactive shuttles of their granular contents. In a viral infection, platelets are activated, and pEVs are generated with occasional virion integration. Both platelets and pEVs are engaged in a bidirectional interaction with neutrophils and other cells of the immune system and the hemostatic pathways. Severe COVID-19 infection is characterized by a stormy thromboinflammatory response with platelets and their EVs at the center stage of this reaction. This review sheds light on the interactions of platelets, pEVS and SARS-CoV-2 infection and prognostic and potential therapeutic role of pEVs. The review also describes the role of pEVs in the rare adenovirus-based COVID-19 vaccine-induced thrombosis thrombocytopenia.
【저자키워드】 COVID-19, SARS-CoV-2, Extracellular vesicles, Platelets, VITT, microparticles, 【초록키워드】 Inflammation, viral infection, thrombosis, SARS-COV-2 infection, neutrophil, immune system, COVID-19 infection, therapeutic, Platelet, bidirectional, extracellular vesicle, prognostic, Interaction, Pathways, virion, Cell, granular, characterized, activated, adenovirus-based, parent cell, 【제목키워드】 Vaccine, COVID-19 infection, extracellular vesicle,