Abstract
Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target.
ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection.
The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.
【저자키워드】 COVID-19, Endotheliitis, Endothelin-1, Endothelin receptor antagonists, 【초록키워드】 Infection, peptide, Kidney injury, Cohort, Patient, plasma, patients, Endothelial cell, Clinical severity, Hypothesis, dysregulation, Support, endothelial, acute phase, clinical benefit, potential therapeutic target, Myocardial, ET-1, died, significantly, elevated, expressed, representing, were measured, stratified, endothelin receptor antagonist, 【제목키워드】 Patient, plasma, hospitalised,