Abstract
Background
With the continuance of the global COVID-19 pandemic, cardiovascular disease (CVD) and cardiac injury have been suggested to be risk factors for severe COVID-19.
Objective
The aim is to evaluate the mortality risks associated with CVD and cardiac injury among hospitalized COVID-19 patients, especially in subgroups of populations in different countries.
Methods
A comprehensive systematic literature search was performed using 9 databases from November 1, 2019 to November 9, 2020. Meta-analyses were performed for CVD and cardiac injury between non-survivors and survivors of COVID-19.
Results
Although the prevalence of CVD in different populations was different, hospitalized COVID-19 patients with CVD were at a higher risk of fatal outcomes (OR = 2.72; 95% CI 2.35–3.16) than those without CVD. Separate meta-analyses of populations in four different countries also reached a similar conclusion that CVD was associated with an increase in mortality. Cardiac injury was common among hospitalized COVID-19 patients. Patients with cardiac injury had a significantly higher mortality risk than those without cardiac injury (OR = 13.25; 95% CI: 8.56–20.52).
Conclusions
Patients’ CVD history and biomarkers of cardiac injury should be taken into consideration during the hospital stay and incorporated into the routine laboratory panel for COVID-19.
【저자키워드】 COVID-19, Mortality, cardiovascular diseases, cardiac injury, Meta analysis, 【초록키워드】 Meta-analysis, Biomarker, severe COVID-19, COVID-19 pandemic, cardiovascular disease, outcome, risk factor, database, Population, Laboratory, Prevalence, hospitalized COVID-19 patient, mortality risk, Injury, Hospital stay, subgroup, CVD, hospitalized COVID-19 patients, higher risk, 95% CI, systematic literature search, survivor, objective, country, non-survivor, Result, performed, evaluate, was performed, suggested, increase in, significantly higher, reached, Separate, 【제목키워드】 Meta-analysis, cardiovascular disease, Acute cardiac injury,