Abstract
Background
The main target of SARS-CoV2 is the alveolar type II (AT2) cells of the lung. SARS-CoV2 evades the innate immune system resulting in the release of proinflammatory cytokines (IL-1β, IL-6, TNF-α) which causes AT2 cell damage. Krebs von den Lungen (KL-6) is a specific biomarker of AT2 cell damage. KL-6 is produced in AT2 cells that are injured/regenerated.
Objective
Research that discusses the role of KL-6 in COVID-19 is still being debated and not much has been done in Indonesia.
Methods
This study was an analytical study with a prospective design on 75 COVID-19 patients who were treated. Subjects were divided into two large groups according to their degree of severity, 57 subjects with severe degrees and 18 subjects with non-severe degrees. The serum KL-6 levels were measured on days 0 and 6. Data were analyzed using paired t-test and independent t-test for data were normally distributed and Wilcoxon test and Mann Whitney test for data that were not normally distributed.
Result
In this study, the mean serum KL-6 for day 0 in the severe group was higher than the non-severe group with values of 45.70 U/mL and 44.85 U/mL. On day 6, the mean serum KL-6 in the severe group was lower than that in the non-severe group with values of 41.3 U/mL and 41.95 U/mL. Serum KL-6 in the severe group experienced an even greater decrease than the non-severe group.
Conclusion
There was no significant association between serum KL-6 values on 0 days in the severity of COVID-19.
【저자키워드】 COVID-19, KL-6, AT2, 【초록키워드】 SARS-CoV2, Biomarker, IL-6, severity, lung, innate immune system, serum, severity of COVID-19, Indonesia, group, TNF-α, association, IL-1β, COVID-19 patient, Proinflammatory cytokine, subject, severe group, t-test, non-severe group, Wilcoxon test, independent t-test, Alveolar Type II, cell damage, objective, Cell, greater decrease, Result, produced, resulting, analyzed, treated, cause, evade, the mean, were measured, normally distributed, prospective design, 【제목키워드】 cross-sectional, serum, Study design, Purposive sampling,