The effect of pretreatment of intravenously administered killed Corynebacterium parvum (CP) and living BCG was studied in various model systems. Both vaccines caused an increased resistance to Listeria monocytogenes, indicating macrophage activation. Only CP exerted a suppressive effect on T-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult T. spiralis worms from intestine). Results of experiments with congenitally athymic (nu/nu) mice and their heterozygous thymus-bearing (+/nu) littermates indicated that CP can induce macrophage activation in the absence of functional T-cells, whereas BCG-induced stimulation is a T-cell-dependent phenomenon.
Stimulation of the non-specific resistance by Corynebacterium parvum and Bacillus calmette Guérin
코리네박테리움 파르붐과 바실루스 칼메트 게랭에 의한 비특이적 저항력의 자극
[Category] 파상풍,
[Source] pubmed
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