Abstract
We described clinical characteristics and outcome of 160 patients over 65 years (01 September to 31 August 2021) who had a first positive SARS-CoV-2 PCR- test more than 14 days after full vaccination and were hospitalized with COVID-19. Median age of included patients was 84 years, 61.2% were over 80 years; 50.6% were male and most (82.5%) has at least one comorbidity. Up to 84% received specific treatment against COVID-19, including 76.9% low-flow oxygen therapy. We found that overall mortality was 25.6% and 30.6% in those older than 80 years. A higher mortality was significantly associated with older age and treatment with tocilizumab. Our data showed that although COVID-19 vaccines continue protecting elderly patients against hospitalization and death and might improve the prognosis after hospitalization in patients with breakthrough infections, mortality in this population -especially in those older than 80 years- remains very high.
【저자키워드】 immunization, COVID-19 vaccines, COVID-19 breakthrough infections, Aged, 【초록키워드】 COVID-19, COVID-19 vaccine, vaccination, Hospitalized, Mortality, Prognosis, Hospitalization, Clinical characteristics, Comorbidity, outcome, male, Patient, Older age, death, breakthrough infections, age, SARS-CoV-2 PCR, Elderly patient, Older, overall mortality, specific treatment, first positive, IMPROVE, described, significantly, low-flow oxygen therapy, treatment with tocilizumab, with COVID-19, 【제목키워드】 Vaccine, Hospitalized, outcome, COVID, Characteristics, clinical, Elderly patient,