Abstract
Background
COVID-19, which is caused by the corona virus 2 that causes severe acute respiratory syndrome, causes a respiratory and systemic illness that in 10–15% of patients escalates to a severe form of pneumonia. Thrombocytopenia is frequent in patients with COVID-19. We aimed to evaluate the association between thrombocytopenia and the severity of COVID-19 infection in hospitalized patients.
Methods
A cross-sectional study was done on 800 Egyptian patients with confirmed covid-19 infection. They were divided into Group I (Mild): 200 symptomatic patients meeting the case definition for COVID-19 without radiological evidence of pneumonia or hypoxia. Group II (Moderate): 200 patients with clinical signs of non-severe pneumonia and radiological evidence of pneumonia. Group III (Severe): 200 patients with clinical signs of pneumonia plus: respiratory or lung dysfunction. Group IV: 200 critically ill patient in ICU: Acute respiratory distress syndrome (ARDS).
Results: there was a highly statistically significant difference between the studied groups regarding thrombocytopenia (p < 0.001). Thrombocytopenia was statistically higher in severe and critically ill patients. In addition, a statistically significant difference found in outcome among the studied groups (p < 0.05) {critically ill (40%), severe (17.5%)}. The most common cause of death was respiratory failure, which occurred in 28 severe patients (80%) and 65 critically ill patients (81.25%), followed by hemorrhage due to thrombocytopenia, which occurred in 7 severe patients (20%) and 15 critically ill patients, respectively (18.75%).
Conclusion
The Platelet count is a straightforward, inexpensive, as well as easily available laboratory parameter that is frequently linked to severe covid-19 infection and a significant death risk.
【저자키워드】 COVID-19, Severe acute respiratory syndrome, Disseminated intravascular coagulopathy, thrombocytopenia, 【초록키워드】 ARDS, Respiratory failure, hypoxia, Pneumonia, cross-sectional, Infection, risk, outcome, hospitalized patients, virus, Laboratory, Critically ill, severity of COVID-19, Patient, death, Severe patient, group, critically ill patients, association, distress, hemorrhage, Critically ill patient, acute respiratory syndrome, syndrome, statistically significant difference, lung dysfunction, parameter, Clinical sign, systemic illness, radiological evidence, evaluate, occurred, caused, addition, cause, statistically, was done, patients with COVID-19, symptomatic patient, 【제목키워드】 Hospitalized, severity, Infection, Patient,