Abstract
Introduction
Apolipoproteins are predictive biomarkers for cardiovascular, neoplasms and cerebrovascular diseases and are postulated as prognostic biomarkers in infectious diseases, as COVID-19. Thus, we assessed the prognosis value of apolipoproteins for COVID-19 severity and mortality.
Methods
We conducted a systematic review and meta-analysis using observational studies that reported the association between apolipoproteins and severity or mortality in COVID-19 patients. Newcastle-Ottawa was used for the quality assessment of included studies. Effects measurements were shown as odds ratios (ORs) with 95% confidence intervals (CIs), and Egger-test was developed for assessing the risk of bias publication.
Results
We analyzed 12 cohort studies (n = 3580). Patients with low ApoliproteinA1 (ApoA1) (OR 0.35; 95%CI 0.24 to 0.49; P < 0.001) and ApoliproteinB (ApoB) (OR = 0.78; 95%CI 0.69 to 0.87; P < 0.001) values had a higher risk of developing severe disease. ApoB/ApoA1 ratio showed no statistically significant association with higher odds of severity. Low ApoA1 levels were associated with higher odds of all-cause mortality (OR = 0.34; 95%CI 0.20 to 0.57; P < 0.001). ApoB values showed no statistically significant association with a high risk of all-cause mortality.
Conclusion
We suggest that adequate levels of ApoA1 and ApoB can be a protective factor for severity in COVID-19, and ApoB/ApoA1 ratio did not show predictive utility for severity.
【저자키워드】 SARS-CoV-2, Mortality, Prognosis, ApoA, ApoB, 【초록키워드】 COVID-19, Meta-analysis, Biomarker, Diseases, severity, COVID-19 severity, systematic review, observational study, cohort study, utility, prognostic biomarker, COVID-19 patients, association, neoplasm, Odds ratio, severe disease, Cerebrovascular disease, high risk, Predictive, 95%CI, higher risk, 95% confidence interval, Apolipoprotein, all-cause mortality, protective factor, Effect, Result, shown, analyzed, was used, reported, conducted, statistically significant, CIs, higher odd, risk of bia, 【제목키워드】 COVID-19, Meta-analysis, systematic review, Apolipoprotein,