ABSTRACT
Background
There are few data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19) infection in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study is to describe the characteristics and outcomes of IPF patients confirmed COVID-19 infection.
Methods
In this retrospective, multi-center, cohort study, patients from 4 hospital medical records with known IPF and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.
Results
Records for 46 patients with IPF and COVID-19 were abstracted. The mean age was 65±10 years. The most common symptom was dyspnea, followed by fever and cough. Ground-glass opacities (n = 35, 83.3%) and consolidations (n = 11, 26.1%) were the main imaging features of the disease in thorax computed tomography (CT). Twenty-four patients (52.1%) required hospitalization. Among the hospitalized patients, 16 (66.6%) were admitted to the intensive care unit (ICU), and 10 (41.6%) underwent invasive mechanical ventilation. Thirteen patients (28.2%) died of COVID-19 complications. Mortality rate was significantly associated with lower DLCO/VA, long term oxygen therapy and consolidation finding on CT of thorax (p<0.05). On multivariable analysis, neither factor was associated with hospitalization or mortality.
Conclusions
IPF patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, ICU requirement, and mortality rate. Measures to minimize the risk of COVID-19 infection remain key to protect IPF patients.
【저자키워드】 SARS-CoV-2, pandemic, Interstitial lung disease, Idiopathic pulmonary fibrosis, outbreak, 【초록키워드】 COVID-19, coronavirus, Mortality, intensive care, Hospitalization, hospital, pulmonary fibrosis, Infection, Symptom, outcome, hospitalized patients, cough, COVID-19 complications, ICU, cohort study, Clinical outcome, Computed tomography, Characteristics, Fever, Dyspnea, Patient, COVID-19 diagnosis, Oxygen therapy, age, mortality rate, electronic medical records, demographic, consolidation, patients, IPF, retrospective, Invasive mechanical ventilation, medical record, Thorax, acute respiratory syndrome, multivariable analysis, measure, Confirmed COVID-19 infection, Record, risk of COVID-19, feature, PROTECT, Result, died, significantly, the disease, required, patients with IPF, 【제목키워드】 outcome, Retrospective study, COVID-19 patient,