Summary
It is unclear why COVID-19 ranges from asymptomatic to severe. When SARS-CoV-2 is detected, interferon (IFN) response is activated. When it is insufficient or delayed, it might lead to overproduction of cytokines and severe COVID-19. The aim was to compare cytokine and IFN patterns in children and adults with differing severity with SARS-CoV-2.It was a prospective, observational study, including 84 patients. Patients with moderate/severe disease had higher cytokines’ values than patients with mild disease (p< 0.001).Two IFN genes were selected to build a decision tree for severity classification: SOCS1 (representative of the rest of the IFN genes) and CIITA (inverse correlation). Low values of CIITA and high values of SOCS1 indicated severe disease. This method correctly classified 33/38(86.8%) of children and 27/34 (79.4%) of adults.
To conclude, patients with severe disease had an elevated cytokine pattern, which correlated with the IFN response, with low CIITA and high SOCS1 values.
【저자키워드】 immunology, Virology, 【초록키워드】 COVID-19, SARS-CoV-2, severe COVID-19, children, severity, interferon, cytokine, Adults, Asymptomatic, Patient, IFN, disease, patients, IFN response, severe disease, inverse correlation, CIITA, SOCS1, Genes, selected, indicated, elevated, activated, correlated, build, with mild disease, 【제목키워드】 children, predict, COVID-19 disease severity, CIITA, SOCS1,