Abstract
Despite endorsed and exponential research to improve diagnostic and therapeutic strategies, efforts have not yet converted into a better prospect for patients infected with the novel coronavirus (2019nCoV), and still, the name of SARS-CoV-2 is coupled with numerous unanswered questions. One of these questions is concerning how this respiratory virus reduces the number of platelets (PLTs)? The results of laboratory examinations showed that about a quarter of COVID-19 cases experience thrombocytopenia, and more remarkably, about half of these patients succumb to the infection due to coagulopathy. These findings have positioned PLTs as a pillar in the management as well as stratifying COVID-19 patients; however, not all the physicians came into a consensus about the prognostic value of these cells. The current review aims to unravel the contributory role of PLTs s in COVID-19; and also to summarize the original data obtained from international research laboratories on the association between COVID-19 and PLT production, activation, and clearance. In addition, we provide a special focus on the prognostic value of PLTs and their related parameters in COVID-19. Questions on how SARS-CoV-2 induces thrombocytopenia are also responded to. The last section provides a general overview of the most recent PLT- or thrombocytopenia-related therapeutic approaches. In conclusion, since SARS-CoV-2 reduces the number of PLTs by eliciting different mechanisms, treatment of thrombocytopenia in COVID-19 patients is not as simple as it appears and serious cautions should be considered to deal with the problem through scrutiny awareness of the causal mechanisms.
【저자키워드】 COVID-19, SARS-CoV-2, Prognosis, pathophysiology, Platelet, thrombocytopenia, 【초록키워드】 Treatment, Infection, diagnostic, Novel coronavirus, Laboratory, Coagulopathy, respiratory virus, management, International, Research, Patient, Therapeutic strategies, mechanisms, association, COVID-19 patient, Consensus, Prognostic value, Activation, therapeutic approaches, These cells, COVID-19 case, effort, physician, clearance, scrutiny, parameter, IMPROVE, addition, appear, provide, question, induce, reduce, concerning, positioned, 【제목키워드】 therapeutic, prognostic, Perspective,