Abstract
Background
It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19).
Methods
We conducted a literature review on https://www.ncbi.nlm.nih.gov/pubmed/, https://scholar.google.com, www.arxiv.org, www.biorxiv.org, of all articles published using the keywords COVID-19 therapy or treatment and cancer until May 2, 2020. A total of 205 articles were identified and 53 were included in this review.
Results
We describe the ongoing COVID-19 therapies that should be known by oncologists and highlight the potential interactions with antineoplastic drugs, commonly used in clinical practice. The main drug interactions were found with tocilizumab, ruxolitinib and colchicine. Conclusions. The literature provides an inconclusive picture on potential preferred treatments for COVID-19 and their interactions with antineoplastic agents. Future clinical trials are needed to better understand the interactions between different drugs in the context of COVID-19 pandemic.
【저자키워드】 angiotensin-converting enzyme 2, interleukin 6, Dipeptidyl peptidase 4, Human immunodeficiency virus, cytochrome P450, ACE2angiotensin-converting enzyme 2, Corona Virus Disease, IL6Interleukin 6, COVID-19corona virus disease, AIFAItalian Medicines Agency (Agenzia Italiana del Farmaco), Italian Medicines Agency (Agenzia Italiana del Farmaco), CPIcheckpoint inhibitors, checkpoint inhibitors, CYPcytochrome P450, ARSIandrogen receptor signaling inhibitors, androgen receptor signaling inhibitors, DMARDsdisease-modifying antirheumatic drugs, disease-modifying antirheumatic drugs, DPP4Dipeptidyl peptidase 4, HIV-1human immunodeficiency virus, 【초록키워드】 COVID-19, Treatment, clinical trial, therapy, Tocilizumab, Immunotherapy, COVID-19 pandemic, Cancer, drug, COVID, Chemotherapy, ruxolitinib, Colchicine, targeted therapy, disease, Clinical practice, Interaction, drug interaction, cancer patient, literature review, article, positive, Future, Inconclusive, oncologist, highlight, Course, Result, conducted, provide, antineoplastic drugs, treatments for COVID-19, 【제목키워드】 therapy, systematic review, COVID 19,