Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone marrow (BM). Trajectories based on single-cell transcriptomes and repertoires of peripheral and BM ASC reveal sequential colonisation of BMPC compartments. In activated B cells, IL-21 suppresses CD19 expression, indicating that CD19^{low}-BMPC are derived from follicular, while CD19^{high}-BMPC originate from extrafollicular immune reactions. In primary immune reactions, both CD19^{low}- and CD19^{high}-BMPC compartments are populated. In secondary immune reactions, most BMPC are recruited to CD19^{high}-BMPC compartments, reflecting their origin from extrafollicular reactivations of memory B cells. A pattern also observable in vaccinated-convalescent individuals and upon diphtheria/tetanus/pertussis recall-vaccination. Thus, BMPC diversity reflects the evolution of a given humoral immune response.
Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow
IL-21 의존적 및 IL-21 비의존적 면역 반응에서 골수로의 플라즈마 세포 모집
[Category] 백일해, 파상풍,
[Source] pubmed
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