Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that can cause both direct and indirect inflammatory damage to multiple organs. Clinical symptoms in the skin, joints, kidneys, and central nervous system, as well as serological indicators such as antinuclear antibodies (ANA), notable antibodies to dsDNA, are used to diagnose SLE. mRNA SARS-CoV-2 vaccines have been shown to trigger SLE flares and the development of new rheumatic diseases. SARS-CoV-2 mRNA vaccinations increase type I interferon (INF), which is not only known to have a role in the antiviral response but is also a crucial cytokine in the pathophysiology of SLE. Furthermore, both the mRNA and adenovirus vaccines boost the production of type 1 interferons, which are required for the spread of SARS-CoV-2. The danger of not administering the COVID-19 vaccination to SLE patients is significantly larger than the likelihood of its adverse effects, which are most likely caused by intrinsic immune failure, demographic disease activity, medications, linked organ damage, and comorbidities. The adverse effects of COVID-19 vaccination in SLE patients are common (about 50%), although they do not interfere with daily functioning in the majority of cases. Several precautions can be taken to avoid the complications associated with COVID-19 vaccinations.
【저자키워드】 COVID-19 vaccine, mRNA vaccine, systemic lupus erythematosus, Lupus flare-up, Autoimmune adverse effects, 【초록키워드】 SARS-CoV-2, Rheumatic diseases, mRNA vaccination, antibody, Comorbidities, interferons, cytokine, Symptom, medications, immune, type I interferon, SARS-CoV-2 vaccine, adverse effects, Spread, Autoimmune disease, COVID-19 vaccination, pathophysiology, mRNA, clinical, Complication, Central nervous system, serological, Precaution, diagnose, boost, Disease activity, antiviral response, Vaccinations, Inflammatory, systemic, SLE, adverse effect, kidneys, multiple organs, organ damage, joints, adenovirus vaccine, likelihood, dsDNA, intrinsic, shown, caused, significantly, required, majority, interfere, notable, SLE patient, with COVID-19, 【제목키워드】 COVID-19, Patient, Precaution, erythematous,