Summary
The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection.
【저자키워드】 SARS-CoV-2, Adaptive immunity, COVID-19 patients, SARS-CoV-2-specific T cells, SARS-CoV-2-specific antibody, 【초록키워드】 antibodies, IgG, Vaccine, T cells, neutralization, SARS-COV-2 infection, SARS-CoV-2 virus, discharged patients, discharge, activity, Cohort, Immunoglobulin, cellular immunity, protective immunity, outbreak, pseudotype, immune responses, Patient, Antibody titer, severe cases, Adaptive immune response, correlation, Blood, Analysis, COVID-19 patient, humoral, World Health Organization, worldwide pandemic, pathogenesis of COVID-19, Follow-up analysis, implication, effective, tested, collected, eight, provide, discharged, 【제목키워드】 COVID-19, detection, individual,