Abstract
Background and aims
The novel coronavirus disease 2019 (COVID-19) has rapidly spread through the whole globe. Since the beginning of the outbreak, some individuals were more likely to manifest more severe outcomes. Diabetic patients were of that sort; however, the severity of COVID-19 in prediabetic ones remained less identified. This study aimed to systematically review and conduct a meta-analysis of the previously published observational studies investigating the severity of COVID-19 in prediabetic patients.
Methods
Medline/PubMed, Scopus, EMBASE, Web of Science, Cochrane library, and google scholar databases were queried to identify relevant studies concerning prediabetes and serious COVID-19 outcomes. The Newcastle-Ottawa scale was used to assess the quality of the included studies. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the likelihood of severe presentations in prediabetic patients.
Results
A total of 3027 patients were included in the meta-analysis. A random-effects model was used regarding the high heterogeneity (I2 = 55%). Prediabetes was significantly associated with adverse outcomes of COVID-19 with an OR of 2.58 (95%CI, 1.46–4.56).
Conclusion
Prediabetes could act as a risk factor for the severity of COVID-19. Early detection of prediabetic patients might be helpful to adopt preventive and protective strategies to improve the prognosis of the infected individuals.
【저자키워드】 COVID-19, Meta-analysis, severity, risk factor, prediabetes, 【초록키워드】 Prognosis, novel coronavirus disease, database, heterogeneity, observational study, adverse outcome, Spread, outcomes, outbreak, severity of COVID-19, Early detection, Patient, patients, Protective, Web of Science, 95%CI, 95% confidence interval, infected individuals, individual, serious COVID-19, random-effects model, likelihood, diabetic patient, IMPROVE, Result, identify, was used, evaluate, globe, significantly, remained, were used, less, concerning, Prediabete, 【제목키워드】 COVID-19 severity, systematic review, risk, Prediabete,