The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
【저자키워드】 viral infection, Laboratory techniques and procedures, 【초록키워드】 diagnostic, FDA, Antigen, COVID-19 testing, Concordance, CDC, molecular, Clinical diagnosis, false-negative, association, Perceived risk, COVID-19 test, Atlanta, repeated, decrease, collected, assays, evaluated, symptomatic patient, 【제목키워드】 SARS-CoV-2, nasal, Impact, quantification, repeated,