We report a traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against β-lactams, cephalosporins (extended-spectrum β-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7). After clinical deterioration using meropenem monotherapy, treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multidrug-resistant S. Typhi.
All Keywords
【저자키워드】 Antibiotic resistance, carbapenems, Enteric fever, S. Typhi, fosfomycin.,
【저자키워드】 Antibiotic resistance, carbapenems, Enteric fever, S. Typhi, fosfomycin.,