Abstract
Post-COVID-19 infection symptoms such as mental fog, tachycardia, and extreme fatigue are just a few of the symptoms wreaking havoc on patients’ lives. Patients with long-term symptoms following COVID-19 are being called long haulers. To date, long haulers are receiving little to no guidance from physicians on their lingering COVID-19 symptoms with limited treatment options available. Zofin is an acellular biologic that contains the extracellular vesicle (EV) fraction of human amniotic fluid and is under investigation for use as a COVID-19 therapeutic. We obtained FDA and IRB approval to investigate the therapeutic use of Zofin in a single long hauler patient case experiencing prolonged shortness of breath and respiratory impairment. Administration of the EV product was shown to be safe. Furthermore, demonstrated respiratory improvements through chest X ray images and oxygen saturation measurement. The single patient IND studies were completed without any reported adverse events or safety concerns. Furthermore, these completed studies demonstrate the feasibility and a therapeutic potential of amniotic fluid-derived EVs for COVID-19 long hauler intervention.
【저자키워드】 COVID-19, Extracellular vesicles, Long COVID, Long-hauler, Perinatal, 【초록키워드】 Treatment, fatigue, feasibility, Infection, Intervention, Symptom, FDA, improvement, oxygen saturation, Chest, therapeutic, adverse event, Patient, Guidance, biologic, Safe, COVID-19 symptom, Shortness of breath, Tachycardia, therapeutic potential, approval, therapeutic use, fraction, respiratory impairment, physician, Mental, Vesicle, IRB, Extracellular, extreme, shown, reported, receiving, demonstrated, amniotic, IND, X ray, 【제목키워드】 biologic, Vesicle, Extracellular, amniotic,