Abstract
Background
Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2.
Methods
Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done.
Results
Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn’t reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01–4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01–7.89, p = 0.42).
Conclusion
No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, COVID pneumonia, Vitamin-D, 【초록키워드】 Vitamin D, disease severity, outcome, invasive ventilation, RCT, Health, Patient, Topic, significant difference, 95%CI, 95% CI, reduce mortality, Result, required, Total, was done, COVID patient, ICU admission rate, 【제목키워드】 systematic review,
【저자키워드】 COVID-19, SARS-CoV-2, COVID pneumonia, Vitamin-D, 【초록키워드】 Vitamin D, disease severity, outcome, invasive ventilation, RCT, Health, Patient, Topic, significant difference, 95%CI, 95% CI, reduce mortality, Result, required, Total, was done, COVID patient, ICU admission rate, 【제목키워드】 systematic review,