Genetic Mechanisms behind the Spread of Reduced Susceptibility to Azithromycin in Shigella Strains Isolated from Men Who Have Sex with Men in Québec, Canada

퀘벡, 캐나다에서 남성과 성관계를 가진 남성에게서 분리된 시겔라 균주에서 아지트로마이신에 대한 감수성 감소의 확산 뒤에 있는 유전적 메커니즘

Published on
Journal: Med Instrum
[저자] Khadidja Yousfi, Christiane Gaudreau, Pierre A Pilon, Brigitte Lefebvre, Matthew Walker, Éric Fournier, Florence Doualla Bell, Christine Martineau, Jean Longtin, Sadjia Bekal
[Category] 세균성이질,
Pubmed URL    DOI URL    
[Source] pubmed

We analyzed 254 Shigella species isolates collected in Québec, Canada, during 2013 and 2014. Overall, 23.6% of isolates showed reduced susceptibility to azithromycin (RSA) encoded by mphA (11.6%), ermB (1.7%), or both genes (86.7%). Shigella strains with RSA were mostly isolated from men who have sex with men (68.8% or higher) from the Montreal region. A complete sequence analysis of six selected plasmids from Shigella sonnei and different serotypes of Shigella flexneri emphasized the role of IS 26 in the dissemination of RSA.

All Keywords
【저자키워드】 Shigella spp, IS26 insertion sequence, plasmid diversity, reduced susceptibility to azithromycin.,