Abstract
Colchicine’s medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine’s future potential applications.
【저자키워드】 Coronary artery disease, Acute coronary syndrome, ACSAcute coronary syndrome, eGFRestimated glomerular filtration rate, estimated glomerular filtration rate, CADcoronary artery disease, COVID-19coronavirus disease - 19, coronavirus disease - 19, DOACsdirect oral anticoagulants, direct oral anticoagulants, NLRP3NOD-, LRR- and pyrin domain-containing protein 3, NOD-, ROCKRho-associated protein kinase, Rho-associated protein kinase, Lp-PLA2Lipoprotein-associated phospholipase A2, Lipoprotein-associated phospholipase A2, 【초록키워드】 Treatment, Evolution, Anti-inflammatory, cardiovascular diseases, therapeutic, Efficacy and safety, Colchicine, Clinical practice, Drug interactions, administration, Safe, complex, recent findings, researcher, presenting, colchicine’, 【제목키워드】 repurposing, drug-to-drug interactions, colchicine’,