Abstract
In 2015, the Nobel Committee for Physiology or Medicine, in its only award for treatments of infectious diseases since six decades prior, honoured the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world’s most devastating tropical diseases. Since March 2020, when IVM was first used against a new global scourge, COVID-19, more than 20 randomized clinical trials (RCTs) have tracked such inpatient and outpatient treatments. Six of seven meta-analyses of IVM treatment RCTs reporting in 2021 found notable reductions in COVID-19 fatalities, with a mean 31% relative risk of mortality vs. controls. During mass IVM treatments in Peru, excess deaths fell by a mean of 74% over 30 days in its ten states with the most extensive treatments. Reductions in deaths correlated with the extent of IVM distributions in all 25 states with p < 0.002. Sharp reductions in morbidity using IVM were also observed in two animal models, of SARS-CoV-2 and a related betacoronavirus. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, possibly yielding full efficacy against emerging viral mutant strains.
【저자키워드】 COVID-19, Ivermectin, SARS-CoV-2, Spike protein, H. pylori, 【초록키워드】 Treatment, Meta-analysis, randomized clinical trial, Efficacy, Diseases, Mortality, risk, animal models, Infectious disease, RCT, Betacoronavirus, Medicine, SARS-CoV-2 spike protein, Physiology, morbidity, death, distribution, mechanism, RCTs, Mutant strains, reduction, competitive binding, tropical, controls, Committee, Seven, indicated, correlated, reductions in, notable, Sharp, yielding, 【제목키워드】 Efficacy, indicated,