Abstract
Background
The corona virus disease 2019 (COVID-19), an acute respiratory disease, caused by a novel corona virus (SARS-CoV-2, previously known as 2019-nCoV), obtained worldwide attention. In this review, we explored the potential siddha strategies for COVID -19 infections.
Objectives
To evaluate the additional benefits of siddha drugs Vasantha kusumakaram mathirai, Thippili rasayanam, Adathodai manapagu and Kabasura kudineer compared to the allopathic standard treatment of care alone in COVID-19 asymptomatic, mild – moderate cases.
Materials and methods
The present study was an open label Two arm – randomized controlled interventional clinical study. The Group I patients were assigned to Siddha add on treatment whereas Group II subjects were assigned with standard treatment alone. The sample size was 100 for each group.
Result
The average number of days taken for reduction of symptoms showed significant results (P < 0.001) in Siddha add on compared with standard treatment. The real – time polymerase chain reaction (RT-PCR) investigation turned negative for 78.33% in Siddha add on and 33.33% in standard treatment after 11–14 days. Similarly, CT chest, covid pattern lung involvement percentage showed highly significant reduction (P < 0.0001) in Siddha add on treatment. In addition, Neutrophil Lymphocyte Ratio (NLR) ratio, showed significant reduction (P < 0.01) when analyzed by Wilcoxon signed rank test, and Renal, Liver parameters were within the normal limits in Siddha add on Group for 25 samples in post treatment.
Conclusion
Finally, it was concluded that Siddha add on Group showed accelerated recovery for COVID - 19 patients compared to standard Group. The synergistic effect of Siddha add on with standard treatment gave more promising results in the current study of COVID -19.
【저자키워드】 COVID-19, synergistic effect, Siddha strategy, Accelerated recovery, 【초록키워드】 Treatment, SARS-CoV-2, lung involvement, 2019-nCoV, Symptom, drug, RT-PCR, COVID, Randomized, infections, Asymptomatic, Patient, Mild, group, Care, moderate, novel corona virus, NLR, clinical study, acute respiratory disease, Virus Disease, reduction, Siddha, Sample size, open label, standard treatment, subject, average, CT chest, material, parameter, objective, benefit, limit, synergistic, polymerase chain, Result, analyzed, evaluate, caused, addition, assigned, accelerated, Ratio, standard treatment alone, 【제목키워드】 clinical evaluation, management, regimen, randomized controlled study, selected,