Recent advances in the pathophysiologic understanding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has indicated that patients with severe coronavirus disease 2019 (COVID-19) might experience cytokine release syndrome (CRS), characterized by increased interleukin (IL)-6, IL-2, IL-7, IL-10, etc. Therefore, the treatment of cytokine storm has been proposed as a critical part of rescuing severe COVID-19. Several of the cytokines involved in COVID-19 employ a distinct intracellular signaling pathway mediated by Janus kinases (JAKs). JAK inhibition, therefore, presents an attractive therapeutic strategy for CRS, which is a common cause of adverse clinical outcomes in COVID-19. Below, we review the possibilities and challenges of targeting the pathway in COVID-19.
【저자키워드】 COVID-19, Cytokine release syndrome, jak inhibitors, 【초록키워드】 Treatment, SARS-CoV-2, Cytokine storm, coronavirus, severe COVID-19, Infection, cytokine, Clinical outcome, Patient, pathway, IL-10, Jak, Critical, therapeutic strategy, IL-2, IL-7, CRS, Janus kinase, acute respiratory syndrome, severe coronavirus disease, intracellular signaling, recent, involved, indicated, characterized, pathophysiologic, 【제목키워드】 Release, Control, Jak-STAT, targeting,