Abstract
Background
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2, has been a significant concern worldwide since its outbreak in December 2019. Various treatments are being researched and developed, and there are reports that dexamethasone has reduced the mortality rate and improved the clinical course of critically ill patients with COVID-19. In this study, we examined the clinical efficacy of corticosteroid therapy for patients with COVID-19 in our hospital during the first wave of infections.
Methods
We retrospectively reviewed the medical records of patients with COVID-19 who were treated with or without corticosteroid therapy at the National Center for Global Health and Medicine in Japan between February and April 2020. The primary outcome was improvement in the patients’ clinical course using a seven-category ordinal scale. We collected data on patient characteristics, treatment, and clinical course, and compared them between two groups: the steroid-using group and the non-steroid-using group.
Results
Between February and April 2020, 110 patients were diagnosed with COVID-19. Despite poor conditions during admission into the steroid group, there were no statistical differences in clinical course between both groups, as measured using the scale. There were no statistical differences between the two groups in the number of days to fever resolution or negative polymerase chain reaction results.
Conclusions
There was no difference in the clinical course between both groups. Because of the difference in background, corticosteroids may potentially make the clinical course of severely ill patients similar to that of mildly ill patients.
【저자키워드】 COVID-19, Corticosteroids, Japan, SARS-CoV 2, 【초록키워드】 Corticosteroid, Dexamethasone, Treatment, Coronavirus disease 2019, coronavirus, hospital, global health, Medicine, Clinical course, infections, Characteristics, outbreak, Fever, Patient, mortality rate, First wave, Admission, Clinical efficacy, medical record, Critically ill patient, acute respiratory syndrome, Primary outcome, both groups, no difference, collected data, center, seven-category ordinal scale, no statistical difference, corticosteroid therapy, polymerase chain, Result, examined, caused, reduced, treated, condition, two group, diagnosed with COVID-19, ill patients, patients with COVID-19, severely ill patient, with COVID-19, 【제목키워드】 Corticosteroid, Infection, outcome, global health, Medicine, clinical, First wave, COVID-19 patient, center,