Objective
To evaluate the safety and efficacy of COVID-19 vaccines in pregnant women performing an updated meta-analysis.
Methods
We searched PubMed, Cochrane Central, and SCOPUS from inception to March 2022. Outcomes of interest were incidence of adverse maternal, fetal and neonatal consequences pertaining to safety of the vaccines. Secondarily, we analyzed the number of SARS-CoV-2 infections, hospitalization for COVID-19, and admission to the I.C.U. for COVID-19 assessing the effectiveness of vaccines. Results were pooled using a random effects model.
Results
Ten observational studies (n=326,499) analyzing pregnant women were included. Our results suggest that COVID-19 vaccination prevents infection (OR: 0.56, 95% CI: 0.47, 0.67; P = <0.00001) and related hospitalizations (OR: 0.50, 95% CI: 0.31, 0.82; P = 0.006) effectively. It was also observed that vaccination does not change adverse outcomes in pregnancy, namely preeclampsia or eclampsia, stroke (four weeks of delivery), meconium-stained amniotic fluid, spontaneous vaginal delivery, operative vaginal delivery, cesarean delivery, postpartum hemorrhage, and blood transfusions. Furthermore, the vaccine was observed to be protective against neonatal COVID-19 I.C.U. admissions (OR: 0.85; 95% CI: 0.81, 0.90; P = <0.00001).
Conclusion
Our pooled analysis suggests that the COVID-19 vaccination in pregnant women prevents infection effectively and has no adverse outcomes. Future large-scale trials in a randomized fashion are needed to confirm our results.
【저자키워드】 COVID-19, Efficacy, Safety, Vaccines, adverse outcomes, Pregnancy, 【초록키워드】 Meta-analysis, COVID-19 vaccine, vaccination, Trial, Hospitalization, stroke, Infection, observational study, adverse outcome, pregnant women, Randomized, COVID-19 vaccination, Effectiveness, incidence, Admission, SARS-CoV-2 infections, Blood, Protective, Analysis, vaginal delivery, Neonatal, postpartum hemorrhage, random effect, Neonatal COVID-19, Future, objective, operative, Prevent, consequence, Result, analyzed, evaluate, searched, the vaccine, fetal, amniotic, 【제목키워드】 Meta-analysis, COVID-19 vaccine, systematic review, Safe, effective, administer,