Abstract
Objective
To qualitatively synthesize and quantitatively evaluate the effect of pulmonary rehabilitation (PR) on dyspnea, lung functions, fatigue, exercise capacity, and quality of life (QoL) in patients with COVID-19.
Data Sources
PubMed, Web of Science, and Cochrane databases were searched from January 2020 to April 2022.
Data Selection
Randomized controlled trials (RCTs) assessing the effect of PR on dyspnea, lung functions, fatigue, exercise capacity, and QoL in patients with COVID-19.
Data Extraction
The mean difference (MD) and a 95% CI were estimated for all the outcome measures using random effect models. The following data were extracted by 2 independent reviewers: (1) first author; (2) publication year; (3) nationality; (4) number of patients included (5) comorbidities; (6) ventilatory support; (7) length of inpatient stay; (8) type of PR; (9) outcome measures; and (10) main findings. The risk of bias was evaluated using the cochrane risk of bias tool.
Data Synthesis
A total of 8 RCTs involving 449 participants were included in the review. PR was found to be significantly effective in improving dyspnea (5 studies, SMD -2.11 [95% CI, -2.96 to -1.27; P<.001]) and exercise capacity (MD 65.85 m [95% CI, 42.86 to 88.83; P<.001]) in patients with both acute and chronic COVID-19 with mild to severe symptoms, whereas fatigue (MD -2.42 [95% CI, -2.72 to -2.11, P<.05]) and lung functions (MD 0.26 L [95% CI, 0.04 to 0.48, P<.05]) were significantly improved in acute COVID-19 patients with mild symptoms. The effect of PR on QoL was inconsistent across studies. PR was found to be safe and feasible for patients with COVID-19.
Conclusion
Evidence from studies indicates that PR program is superior to no intervention in improving dyspnea, exercise capacity, lung functions, and fatigue in patients with COVID-19. PR appears to be safe and beneficial for both acute and chronic COVID-19 patients.
【저자키워드】 Randomized controlled trial, Quality of life, pulmonary rehabilitation, 6-minute walk test, chronic obstructive pulmonary disease, forced vital capacity, COPDchronic obstructive pulmonary disease, RCTrandomized controlled trial, 6MWT6-minute walk test, FVCForced vital capacity, PRpulmonary rehabilitation, QoLquality of life, SFShort-Form Health Survey, Short-Form Health Survey, SGRQSt. George's Respiratory Questionnaire, St. George's Respiratory Questionnaire, 【초록키워드】 COVID-19, fatigue, Exercise capacity, lung, Intervention, outcome, database, RCT, Lung function, Dyspnea, Patient, Controlled trial, Mild, Selection, synthesis, mild symptoms, COVID-19 patients, RCTs, Safe, Web of Science, 95% CI, severe symptoms, extraction, outcome measure, participant, ventilatory, mean difference, functions, acute COVID-19, random effect, SMD, objective, effective, independent, significantly, evaluated, appear, indicate, searched, feasible, Source, evaluate the effect, patients with COVID-19, risk of bia, 【제목키워드】 review, exercise, pulmonary, Capacity, Quality, life, Effect,