Abstract
Background
Even though COVID-19 clinical features, pathogenesis, complications, and therapeutic options have been largely described in the literature, long-term consequences in patients remain poorly known.
Methods
The French, multicentre, non-interventional SISCOVID study evaluated lung impairment three (M3) and six months (M6) after hospital discharge in patients recovered from COVID-19. Evaluation was based on clinical examination, pulmonary function tests, and chest computed tomography (CT-scan).
Results
Of the 320 included patients (mean age: 61 years; men: 64.1%), 205 had had a severe form of COVID-19, being hospitalised in an intensive care unit (ICU), and requiring high flow nasal cannula, non-invasive ventilation, or invasive mechanical ventilation. At M6, 54.1% of included patients had persistent dyspnoea (mMRC score ≥1), 20.1% severe impairment in gas diffusing capacity (DLCO <60% pred.), 21.6% restrictive ventilatory pattern (total lung capacity <80% pred.), and 40% a fibrotic-like pattern at CT-scan. Fibrotic-like pattern and restrictive ventilatory pattern were significantly more frequent in patients recovered from severe than non-severe COVID-19. Improved functional and radiological outcomes were observed between M3 and M6. At M6, age was an independent risk factor for severe DLco impairment and fibrotic-like pattern and severe COVID-19 form was independent risk factor for restrictive ventilatory profile and fibrotic-like pattern.
Conclusion
Six months after discharge, patients hospitalised for COVID-19, especially those recovered from a severe form of COVID-19, frequently presented persistent dyspnoea, lung function impairment, and persistent fibrotic-like pattern, confirming the need for long-term post-discharge follow-up in these patients and for further studies to better understand long-term COVID-19 lung impairment.
【저자키워드】 COVID-19, Pneumonia, observational study, sequelae, Patient discharge, 【초록키워드】 Pathogenesis, intensive care, severe COVID-19, lung, nasal, outcome, discharge, Clinical features, ICU, Chest computed tomography, Lung function, Patient, non-invasive ventilation, complications, age, multicentre, Follow-up, CT-scan, Dyspnoea, Invasive mechanical ventilation, therapeutic option, Pulmonary function tests, hospital discharge, ventilatory, independent risk factor, French, impairment, clinical examination, mMRC, hospitalised, consequence, radiological, lung capacity, Result, described, significantly more, evaluated, functional, Improved, diffusing, 【제목키워드】 Cohort, hospitalisation, French,