Abstract
The ISCT Scientific Signature Series Symposium “Advances in Cell and Gene Therapies for Lung Diseases and Critical Illnesses” was held as an independent symposium in conjunction with the biennial meeting, “Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases,” which took place July 12–15, 2021, at the University of Vermont. This is the third Respiratory System–based Signature Series event; the first 2, “Tracheal Bioengineering, the Next Steps” and “Cellular Therapies for Pulmonary Diseases and Critical Illnesses: State of the Art of European Science,” took place in 2014 and 2015, respectively. Cell- and gene-based therapies for respiratory diseases and critical illnesses continue to be a source of great promise and opportunity. This reflects ongoing advancements in understanding of the mechanisms by which cell-based therapies, particularly those using mesenchymal stromal cells (MSCs), can mitigate different lung injuries and the increasing sophistication with which preclinical data is translated into clinical investigations. This also reflects continuing evolution in gene transfer vectors, including those designed for in situ gene editing in parallel with those targeting gene or cell replacement. Therefore, this symposium convened global thought leaders in a forum designed to catalyze communication and collaboration to bring the greatest possible innovation and value of cell- and gene-based therapies for patients with respiratory diseases and critical illnesses.
【저자키워드】 Critical illness, Cell therapy, Lung disease, Gene therapy, Mesenchymal stromal cell, 【초록키워드】 Evolution, therapy, MSCs, Lung injury, pulmonary, Biology, Respiratory disease, Patient, respiratory, Critical, bioengineering, mechanism, stromal cell, transfer, signature, illnesses, vectors, symposium, preclinical data, mitigate, state, European, Cell, cell-based therapies, independent, ISCT, thought, translated, illness, reflect, biennial, Sery, took place, University of Vermont, 【제목키워드】 Critical, Society, Cell, ISCT, Proceeding,