Kidney organoids derived from pluripotent stem cells and epithelial organoids derived from adult tissue (tubuloids) have been used to study various kidney disorders with a strong genetic component, such as polycystic kidney disease, Wilms tumor, and congenital nephrotic syndrome. However, complex disorders without clear genetic associations, such as acute kidney injury and many forms of chronic kidney disease, are only just beginning to be investigated using these in vitro approaches. Although organoids are a reductionist model, they contain clinically relevant cell populations that may help to elucidate human-specific pathogenic mechanisms. Thus, organoids may complement animal disease models to accelerate the translation of laboratory proof-of-concept research into clinical practice. This review discusses whether kidney organoids and tubuloids are suitable models for the study of complex human kidney disease and highlights their advantages and limitations compared with monolayer cell culture and animal models.
【초록키워드】 translation, complement, Acute kidney injury, Chronic kidney disease, animal models, in vitro, Laboratory, Cell culture, Research, Disease model, disease, epithelial, Clinical practice, genetic associations, Organoid, tissue, approaches, complex, syndrome, help, limitation, pathogenic mechanisms, genetic component, cell population, human kidney, polycystic kidney disease, pluripotent stem cell, highlight, investigated, clinically, form, accelerate, complex disorder, kidney disorder, kidney organoid, 【제목키워드】 Human, Model, Organoid,