A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand

IL1B 유전자 프로모터의 기능적 다형성인 IL1B -31C>T는 태국에서 뇌 말라리아와 관련이 없다.

Published on
Journal: Malaria Journal
[저자] Jun Ohashi, Izumi Naka, Akihiro Doi, Jintana Patarapotikul, Hathairad Hananantachai, Noppadon Tangpukdee, Sornchai Looareesuwan, Katsushi Tokunaga
[Category] 말라리아,
PMC URL    Pubmed URL    [DOI] 10.1186/1475-2875-4-38    
[Article Type] Research
[Source] PMC

Background IL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1 , IL1B -31C>T. Methods To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malaria and 203 mild malaria patients). Results In this population, IL1B -31C>T and IL1RA VNTRwere detected, while IL1B 3953C>T (i.e., IL1B 3953T) was not observed in the polymorphism screening for 32 patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients showed no significant association of these polymorphisms with cerebral malaria. Conclusion The present results suggest that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria.

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