Abstract
As brutally demonstrated by the COVID-19 pandemic, an effective immune system is essential for survival. Developed over evolutionary time, viral nucleic acid detection is a central pillar in the defensive armamentarium used to combat foreign microbial invasion. To ensure cellular homeostasis, such a strategy necessitates the efficient discrimination of pathogen-derived DNA and RNA from that of the host. In 2011, it was suggested that an upregulation of type I interferon signalling might serve as a defining feature of a novel set of Mendelian inborn errors of immunity, where antiviral sensors are triggered by host nucleic acids due to a failure of self versus non-self discrimination. These rare disorders have played a surprisingly significant role in informing our understanding of innate immunity and the relevance of type I interferon signalling for human health and disease. Here we consider what we have learned in this time, and how the field may develop in the future.
【초록키워드】 Immunity, Antiviral, Innate immunity, COVID-19 pandemic, immune system, type I interferon, Health, survival, disease, Invasion, microbial, viral nucleic acid, upregulation, disorder, Host, DNA and RNA, effective, cellular homeostasis, develop, demonstrated, suggested, triggered, Developed, host nucleic acid, 【제목키워드】 type I,