Abstract
Despite the introduction of vaccines, COVID-19 still affects millions of people worldwide. A better understanding of pathophysiology and the discovery of novel therapies are needed. One of the cells of interest in COVID-19 is the neutrophil. This cell type is being recruited to a site of inflammation as one of the first immune cells. In this project, we investigated a variety of neutrophils phenotypes during COVID-19 by measuring the expression of markers for migration, maturity, activation, gelatinase granules and secondary granules using flow cytometry. We show that neutrophils during COVID-19 exhibit altered phenotypes compared to healthy individuals. The activation level including NETs production and maturity of neutrophils seem to last longer during COVID-19 than expected for innate immunity. Neutrophils as one of the drivers of severe cases of COVID-19 are considered as potential treatment targets. However, for a successful implementation of treatment, there is a need for a better understanding of neutrophil functions and phenotypes in COVID-19. Our study answers some of those questions.
【초록키워드】 COVID-19, Treatment, Inflammation, therapy, Vaccines, Innate immunity, neutrophil, flow cytometry, Migration, pathophysiology, implementation, phenotype, immune cells, targets, expression, marker, Potential treatment, Activation, healthy individuals, Severe case, NET, Affect, neutrophil function, Cell, recruited, investigated, variety, expected, driver, gelatinase, Granule, 【제목키워드】 COVID-19, systemic immune response,