Abstract
Respiratory diseases remain a major cause of morbidity and mortality worldwide. An imbalance of zinc, an essential trace element, is associated with a variety of lung diseases. We reviewed and summarized recent research (human subjects, animal studies, in vitro studies) on zinc in respiratory diseases to explore the protective mechanism of zinc from the perspective of regulation of oxidative stress, inflammation, lipid metabolism, and apoptosis. In the lungs, zinc has anti-inflammatory, antioxidant, and antiviral effects; can inhibit cancer cell migration; can regulate lipid metabolism and immune cells; and exerts other protective effects. Our comprehensive evaluation highlights the clinical and experimental effects of zinc in the pathogenesis of respiratory diseases. Our analysis also provides insight into the clinical application of zinc-targeted therapy for respiratory diseases.
【초록키워드】 Apoptosis, Inflammation, therapy, Pathogenesis, Anti-inflammatory, Antiviral, oxidative stress, antioxidant, respiratory diseases, immune, Protective effects, Lungs, Lung diseases, Respiratory disease, Research, morbidity and mortality, respiratory, disease, Analysis, regulate, lipid metabolism, protective mechanism, In vitro studies, Regulation, Perspective, Effect, highlight, inhibit, provide, subjects, variety, cancer cell, 【제목키워드】 Pathogenesis, Respiratory disease,