Abstract
Skin antiseptics have important implications for public health and medicine. Although conventional antiseptics have considerable antimicrobial activity, skin toxicity and the development of resistance are common problems. Plasma-treated water has sterilization and tissue-regenerative effects. Therefore, the aim of this study was to identify whether plasma-activated water (PAW) manufactured by our microwave plasma system can be used as a novel antiseptic solution for skin protection. PAW was produced by dissolving reactive nitrogen oxide gas using microwave plasma in deionized water. The antibacterial effects of PAW against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Salmonella typhimurium and effective concentrations were investigated by a solid agar plate assay. The factors mediating the effects of PAW were evaluated by the addition of reactive species scavengers. Cytotoxicity and cell viability assays were performed to examine the protective effect of PAW on normal skin cells. PAW exhibited excellent sterilization and no toxicity in normal skin cells. Experiments also confirmed the potential of PAW as a sanitizer for SARS-CoV-2. Our findings support the use of PAW as an effective skin disinfectant with good safety in the current situation of a global pandemic.
【초록키워드】 public health, SARS-CoV-2, Toxicity, global pandemic, cells, viability, plasma, skin, protective effect, Concentration, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Salmonella Typhimurium, Support, Factor, problems, Effect, Effects, implication, effective, Cell, reactive, Bacillus cereus, produced, identify, performed, addition, investigated, evaluated, exhibited, can be used, reactive nitrogen, 【제목키워드】 antimicrobial, pandemic era, protective effect, Effect,