Pseudopeptide chemistry is gaining ground in the field of synthetic vaccine development. We have previously demonstrated the potential scope of introducing reduced amide peptide bond isosters in a site-directed design for obtaining structurally modified probes able to induce malaria infection-neutralizing antibodies derived from the MSP-1 antigen. This work reports the functional properties of polyclonal and monoclonal antibodies induced by site-directed designed MSP-2 N-terminus pseudopeptides and their capacity for antibody isotype switching in in vitro immunization. Structural properties of the native peptide and its pseudopeptide analogs are discussed within the context of these novel pseudopeptides’ induced monoclonal antibody functional and physical-chemical properties.
Antibodies induced by Plasmodium falciparum merozoite surface antigen-2-designed pseudopeptides possess neutralizing properties of the in vitro malarial infection
플라스모디움 팔시파룸 메로조이트 표면 항원-2로 설계된 의사펩타이드에 의해 유도된 항체는 시험관 내 말라리아 감염에 대한 중화 특성을 가지고 있다.
[Category] 말라리아,
[Article Type] journal-article
[Source] pubmed
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