Abstract
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
All Keywords
【초록키워드】 COVID-19, convalescent plasma, antibodies, SARS-CoV-2, Efficacy, coronavirus, B.1.351, neutralization, variant, Spike protein, Reinfection, pseudovirus, 501Y.V2, binding, domain, Substitution, spike-based vaccines, immunodominant, Complete, highlight, reduced, the spike protein, expressing, exhibit, novel lineage, 【제목키워드】 COVID-19, SARS-CoV-2, neutralization, 501Y.V2, African, plasma, Donor, South,
【초록키워드】 COVID-19, convalescent plasma, antibodies, SARS-CoV-2, Efficacy, coronavirus, B.1.351, neutralization, variant, Spike protein, Reinfection, pseudovirus, 501Y.V2, binding, domain, Substitution, spike-based vaccines, immunodominant, Complete, highlight, reduced, the spike protein, expressing, exhibit, novel lineage, 【제목키워드】 COVID-19, SARS-CoV-2, neutralization, 501Y.V2, African, plasma, Donor, South,